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pentobarbital will decrease the extent or impact of bosentan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Importance Not known.Observe Closely (1)pentobarbital will lower the extent or effect of fentanyl intranasal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Intently. Coadministrat